A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway.
The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. Beta-catenin is a protein that regulates both transcription of many genes and cell-cell adhesion; in response to an external Wnt stimulus the intracellular levels of beta-catenin are controlled by the proteins which make up the Wnt/beta-catenin signalling pathway. In this paper we present a systematic asymptotic analysis of an exi...Expand abstract
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