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A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway.

Abstract:

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. Beta-catenin is a protein that regulates both transcription of many genes and cell-cell adhesion; in response to an external Wnt stimulus the intracellular levels of beta-catenin are controlled by the proteins which make up the Wnt/beta-catenin signalling pathway. In this paper we present a systematic asymptotic analysis of an exi...

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Publication status:
Published

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Publisher copy:
10.1007/s00285-009-0262-y

Authors


Mirams, GR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Journal of mathematical biology
Volume:
60
Issue:
1
Pages:
131-160
Publication date:
2010-01-05
DOI:
EISSN:
1432-1416
ISSN:
0303-6812
URN:
uuid:247a68d8-dd24-4374-96a7-4cc91eacc470
Source identifiers:
188081
Local pid:
pubs:188081

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