Journal article
ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys
- Abstract:
- Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection against a lethal challenge with NiV Bangladesh (NiV-B) in hamsters. Here, we investigated the efficacy of ChAdOx1 NiV in the lethal African green monkey (AGM) NiV challenge model. AGMs were vaccinated either 4 weeks before challenge (prime vaccination), or 8 and 4 weeks before challenge with ChAdOx1 NiV (prime-boost vaccination). A robust humoral and cellular response was detected starting 14 days post-initial vaccination. Upon challenge, control animals displayed a variety of signs and had to be euthanized between 5 and 7 days post inoculation. In contrast, vaccinated animals showed no signs of disease, and we were unable to detect infectious virus in tissues and all but one swab. No to limited antibodies against fusion protein or nucleoprotein antigen could be detected 42 days post challenge, suggesting that vaccination induced a very robust protective immune response preventing extensive virus replication.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s41541-022-00592-9
Authors
+ Coalition for Epidemic Preparedness Innovations
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- Funder identifier:
- https://ror.org/01t08q012
- Grant:
- 276871
+ National Institute of General Medical Sciences
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- Funder identifier:
- https://ror.org/04q48ey07
- Publisher:
- Springer Nature
- Journal:
- npj Vaccines More from this journal
- Volume:
- 7
- Issue:
- 1
- Article number:
- 171
- Place of publication:
- England
- Publication date:
- 2022-12-21
- Acceptance date:
- 2022-12-06
- DOI:
- EISSN:
-
2059-0105
- Pmid:
-
36543806
- Language:
-
English
- Pubs id:
-
1317439
- Local pid:
-
pubs:1317439
- Source identifiers:
-
W4312112841
- Deposit date:
-
2026-04-01
- ARK identifier:
Terms of use
- Copyright holder:
- van Doremalen et al.
- Copyright date:
- 2022
- Rights statement:
- © the author (s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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