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The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel

Abstract:

The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K(+) channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism located wit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/19336950.2017.1356955

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
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Institution:
University of Oxford
Oxford college:
Green Templeton College
Role:
Author
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Funding agency for:
Sansom, M
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Funding agency for:
Tucker, S
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Publisher:
Taylor and Francis Publisher's website
Journal:
Channels Journal website
Volume:
11
Issue:
5
Pages:
482-486
Publication date:
2017-07-19
Acceptance date:
2017-07-13
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
Source identifiers:
709467
Language:
English
Keywords:
Pubs id:
pubs:709467
UUID:
uuid:2470bd7b-0345-4cde-953c-0d9362f36498
Local pid:
pubs:709467
Deposit date:
2017-08-07

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