Journal article
The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
- Abstract:
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The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K(+) channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism located wit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1080/19336950.2017.1356955
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Sansom, M
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Tucker, S
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Bibliographic Details
- Publisher:
- Taylor and Francis Publisher's website
- Journal:
- Channels Journal website
- Volume:
- 11
- Issue:
- 5
- Pages:
- 482-486
- Publication date:
- 2017-07-19
- Acceptance date:
- 2017-07-13
- DOI:
- EISSN:
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1933-6969
- ISSN:
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1933-6950
- Source identifiers:
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709467
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:709467
- UUID:
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uuid:2470bd7b-0345-4cde-953c-0d9362f36498
- Local pid:
- pubs:709467
- Deposit date:
- 2017-08-07
Terms of use
- Copyright holder:
- Nematian-Ardestani et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Nematian-Ardestani et al. Published with license by Taylor & Francis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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