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Network analysis of the CSF proteome characterizes convergent pathways of cellular dysfunction in ALS

Abstract:

Background: Amyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterized by TDP-43 pathology. The identification in CSF of a protein signature of TDP-43 network dysfunction would have the potential to inform the identification of new biomarkers and therapeutic targets. Methods: We compared CSF proteomic data from patients with ALS (n = 41), Parkinson’s disease (n = 19) and healthy control participants (n = 20). Weighted c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0003-1063-3277
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-5490-1697
Publisher:
Frontiers Media
Journal:
Frontiers in Neuroscience More from this journal
Volume:
15
Article number:
642324
Publication date:
2021-03-17
Acceptance date:
2021-02-18
DOI:
EISSN:
1662-453X
ISSN:
1662-4548
Pmid:
33815045
Language:
English
Keywords:
Pubs id:
1171339
Local pid:
pubs:1171339
Deposit date:
2021-04-23

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