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Selective inhibition of factor inhibiting hypoxia-inducible factor.

Abstract:

A set of four non-heme iron(II) and 2-oxoglutarate-dependent enzymes catalyze the post-translational modification of a transcription factor, hypoxia inducible factor (HIF), that mediates the hypoxic response in animals. Hydroxylation of HIF both causes its degradation and limits its activity. We describe how the use of structural data coupled to solid-phase synthesis led to the discovery of a selective inhibitor of one of the HIF hydroxylases. The inhibitor N-oxalyl-d-phenylalanine was shown ...

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Publication status:
Published

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Publisher copy:
10.1021/ja050841b

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Journal:
Journal of the American Chemical Society More from this journal
Volume:
127
Issue:
21
Pages:
7680-7681
Publication date:
2005-06-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Keywords:
Pubs id:
pubs:33108
UUID:
uuid:2463d0bf-e2c1-4ec9-b05d-270d956639a7
Local pid:
pubs:33108
Source identifiers:
33108
Deposit date:
2012-12-19

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