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A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

Abstract:

Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-04088-w

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-8945-0010
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Role:
Author
ORCID:
0000-0002-3757-541X
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National Health More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
1597
Publication date:
2018-04-23
Acceptance date:
2018-04-03
DOI:
ISSN:
2041-1723
Pmid:
29686427
Source identifiers:
844918
Language:
English
Keywords:
Pubs id:
pubs:844918
UUID:
uuid:245361ad-27fe-4489-86a1-7a6b55e21d5a
Local pid:
pubs:844918
Deposit date:
2018-05-15

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