Simple transformations capture auditory input to cortex

Journal article

Sounds are processed by the ear and central auditory pathway. These processing steps are biologically complex, and many aspects of the transformation from sound waveforms to cortical response remain unclear. To understand this transformation, we combined models of the auditory periphery with various encoding models to predict auditory cortical responses to natural sounds. The cochlear models ranged from detailed biophysical simulations of the cochlea and auditory nerve to simple spectrogram-like approximations of the information processing in these structures. For three different stimulus sets, we tested the capacity of these models to predict the time course of single-unit neural responses recorded in ferret primary auditory cortex. We found that simple models based on a log-spaced spectrogram with approximately logarithmic compression perform similarly to the best-performing biophysically detailed models of the auditory periphery, and more consistently well over diverse natural and synthetic sounds. Furthermore, we demonstrated that including approximations of the three categories of auditory nerve fiber in these simple models can substantially improve prediction, particularly when combined with a network encoding model. Our findings imply that the properties of the auditory periphery and central pathway may together result in a simpler than expected functional transformation from ear to cortex. Thus, much of the detailed biological complexity seen in the auditory periphery does not appear to be important for understanding the cortical representation of sound.

Authors: Rahman, M; Willmore, BDB; King, AJ; Harper, NS

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: National Academy of Sciences
• Journal: Proceedings of the National Academy of Sciences
• Volume: 117
• Issue: 45
• Article number: 28442-28451
• Publication date: 2020-10-23
• Acceptance date: 2020-09-18
• DOI: 10.1073/pnas.1922033117
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: predicting responses to natural sounds; auditory cortex; encoding models of neural responses; models of the auditory periphery; FFR; Marr’s levels of analysis