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Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses

Abstract:

IgG4 antibodies are unique to humans. IgG4 is associated with tolerance during immunotherapy in allergy, but also with pathology, as in pemphigus vulgaris and IgG4‐related disease. Its induction is largely restricted to non‐microbial antigens, and requires repeated or prolonged antigenic stimulation, for reasons poorly understood. An important aspect in generating high‐affinity IgG antibodies is chemokine receptor‐mediated migration of B cells into appropriate niches, such as germinal centers...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201948454

Authors


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Name:
National Institute for Health Research
Grant:
NF-SI-0617-10139
Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
50
Issue:
8
Pages:
1113-1125
Publication date:
2020-05-25
Acceptance date:
2020-04-14
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
32289181
Language:
English
Keywords:
Pubs id:
1100365
Local pid:
pubs:1100365
Deposit date:
2020-04-20

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