Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise.

Journal article

BACKGROUND AND PURPOSE: The Normal Tissue Complication Probability (NTCP) for rectum is usually defined for late rectal bleeding. This study calculates NTCP parameter values for additional rectal toxicity endpoints observed in clinical practise. MATERIALS AND METHODS: 388 patients from the multicentre MRC-RT01 prostate conformal radiotherapy trial (ISRCTN 47772397) were used to derive independent Lyman Kutcher Burman model (LKB) parameters for five late rectal toxicity endpoints: rectal bleed...

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Authors: Gulliford, S; Partridge, M; Sydes, MR; Webb, S; Evans, P

• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• Volume: 102
• Issue: 3
• Pages: 347-351
• Publication date: 2012-03-01
• DOI: 10.1016/j.radonc.2011.10.022
• EISSN: 1879-0887
• ISSN: 0167-8140
• Language: English
• Keywords: Prostatic Neoplasms; Probability; Radiotherapy, Conformal; Endpoint Determination; Humans; Gastrointestinal Hemorrhage; Male; Likelihood Functions; Rectum