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Journal article

Immunogenicity in Mamu-A*01 rhesus macaques of a CCR5-tropic human immunodeficiency virus type 1 envelope from the primary isolate (Bx08) after synthetic DNA prime and recombinant adenovirus 5 boost.

Abstract:

Envelopes of primary R5-tropic human immunodeficiency virus type 1 (HIV-1) isolates may be particularly relevant for vaccine purposes and should be evaluated for immunogenicity in animals including macaques before carrying out human vaccine trials. In the present study, the immunogenicities of synthetic HIV-1 env DNA vaccines, which had been derived from the early primary isolate Bx08 and contain humanized codons, were evaluated in mice, guinea pigs and rhesus macaques. Neutralization sensiti...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.18589-0

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Journal:
The Journal of general virology
Volume:
84
Issue:
Pt 1
Pages:
203-213
Publication date:
2003-01-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:243f240d-09f1-4f32-bbb7-ab0f10010a06
Source identifiers:
67020
Local pid:
pubs:67020

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