High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.

Journal article

BACKGROUND and AIMS: Cellular immune responses are thought to play a key role in the resolution of primary HCV infection. Although it has been consistently shown that CD4+ T-cell responses are maintained in those with spontaneous resolution but lost in those with persistent infection, the role of CD8+ T-cell responses remains controversial. Previous studies have largely focused on limited HLA alleles and predefined CD8+ T-cell epitopes, and, thus, comprehensive studies remain to be performed....

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Authors: Lauer, G; Barnes, E; Lucas, M; Timm, J; Ouchi, K

• Publication status: Published
• Journal: Gastroenterology
• Volume: 127
• Issue: 3
• Pages: 924-936
• Publication date: 2004-09-01
• DOI: 10.1053/j.gastro.2004.06.015
• EISSN: 1528-0012
• ISSN: 0016-5085
• Language: English
• Keywords: Hepacivirus; HLA Antigens; CD8-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Humans; Immunity, Cellular; Remission, Spontaneous; Hepatitis C