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Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth

Abstract:

Over 20% of cancer patients will suffer metastatic spread to the brain, and prognosis remains poor. Communication between tumour cells and host tissue is essential during metastasis, yet little is known of the processes underlying such interactions in the brain. Here we test the hypothesis that cross-talk between tumour cells and host brain cells, through tumour cell leukocyte function associated protein-1 (LFA-1), is critical in metastasis devel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.10737

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Name:
Cancer Research UK
Grant:
C5255/A12678
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Publication date:
2016-06-01
Acceptance date:
2016-06-27
DOI:
ISSN:
1949-2553
Keywords:
Pubs id:
pubs:632309
UUID:
uuid:243224c1-19da-46f4-a48f-36779d26ad5d
Local pid:
pubs:632309
Source identifiers:
632309
Deposit date:
2016-07-07

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