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Neuro-symbolic federated learning over heterogeneous data-views: a structured approach to distributive EHR modelling

Abstract:

Federated learning (FL) enables privacy-preserving model training across distributed Electronic Health Records (EHRs), but its deployment remains limited by data-view heterogeneity, where institutions maintain incompatible local schemas. Most existing methods address this by enforcing flat, aligned data views, which require extensive cross-site preprocessing and manual harmonisation that often discards clientspecific features, or by projecting inputs into a shared latent space, which sacrifices interpretability. We propose a modelling shift from conventional FL with vectorised inputs to a symbolic, relation-centric framework, where each client organises its EHR data as a structured, type-aware relational graph. This enables client-specific inference without requiring schema alignment and supports FL across heterogeneous data views. To model over these symbolic structures, we introduce an architecture that combines relation-aware message passing with a learnable feature relevance mechanism, jointly enabling accurate local predictions and client-specific interpretability while supporting parameter sharing across clients. Beyond strong performance on three real-world EHR datasets exhibiting data-view heterogeneity, we further show that our framework supports multimodal FL under modalitylevel heterogeneity. Using MC-MED, a publicly available multimodal emergency department dataset, we demonstrate that our method accommodates clients with partially missing modalities, highlighting its robustness and scalability in realworld clinical settings.

Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1609/aaai.v40i29.39624

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author


Publisher:
Association for the Advancement of Artificial Intelligence
Host title:
Proceedings of the 40th Annual AAAI Conference on Artificial Intelligence
Volume:
40
Issue:
29
Pages:
24422-24430
Publication date:
2026-03-14
Acceptance date:
2025-11-09
Event title:
40th Annual AAAI Conference on Artificial Intelligence (AAAI 2026)
Event location:
Singapore
Event website:
https://aaai.org/conference/aaai/aaai-26/
Event start date:
2026-01-20
Event end date:
2026-01-27
DOI:
EISSN:
2374-3468
ISSN:
2159-5399
ISBN-10:
1577359062
ISBN-13:
9781577359067


Language:
English
Pubs id:
2362085
Local pid:
pubs:2362085
Deposit date:
2026-01-19
ARK identifier:

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