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Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases

Abstract:

Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for the treatment of AS. Here we investigate the therapeutic potential of four different JAK inhibitors on cells derived from AS patients and healthy controls, cultured in-vitro under Th17-promoting cond...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Edmund Hall
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Ridley, A
Bowness, P
Grant:
Oxford Biomedical Research Centre
More from this funder
Name:
Deutsche Forschungsgemeinschaft
Funding agency for:
Hammitzsch, A
Grant:
HA-7021/1-1
More from this funder
Name:
Wellcome Trust
Grant:
MHA 102288/Z/13/Z
More from this funder
Name:
Società Italiana di Reumatologia
Funding agency for:
Simone, D
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Publication date:
2018-10-23
Acceptance date:
2018-09-07
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:927481
UUID:
uuid:2420862b-2a77-4e50-8603-f95b8f56b757
Local pid:
pubs:927481
Deposit date:
2018-10-15

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