- Abstract:
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Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for the treatment of AS. Here we investigate the therapeutic potential of four different JAK inhibitors on cells derived from AS patients and healthy controls, cultured in-vitro under Th17-promoting cond...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.3mb)
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- Publisher copy:
- 10.1038/s41598-018-34026-1
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Publication date:
- 2018-10-23
- Acceptance date:
- 2018-09-07
- DOI:
- EISSN:
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2045-2322
- Pubs id:
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pubs:927481
- URN:
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uri:2420862b-2a77-4e50-8603-f95b8f56b757
- UUID:
-
uuid:2420862b-2a77-4e50-8603-f95b8f56b757
- Local pid:
- pubs:927481
- Copyright holder:
- Hammitzsch et al.
- Copyright date:
- 2018
- Notes:
- © The Authors 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
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