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Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases

Abstract:

Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for the treatment of AS. Here we investigate the therapeutic potential of four different JAK inhibitors on cells derived from AS patients and healthy controls, cultured in-vitro under Th17-promoting cond...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-34026-1

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Edmund Hall
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
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Grant:
MHA 102288/Z/13/Z
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Publication date:
2018-10-23
Acceptance date:
2018-09-07
DOI:
EISSN:
2045-2322
Pubs id:
pubs:927481
URN:
uri:2420862b-2a77-4e50-8603-f95b8f56b757
UUID:
uuid:2420862b-2a77-4e50-8603-f95b8f56b757
Local pid:
pubs:927481

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