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Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects.

Abstract:

Substance P (SP) has memory-promoting, reinforcing and anxiolytic-like effects when applied systemically or centrally. Such effects may be mediated by the neurokinin-1 (NK-1) receptor, since SP preferentially binds to this receptor. We measured the effects of a selective non-peptide NK-1 receptor antagonist, SR140333 (1, 3 and 9 mg/kg i.p.) on ACh levels in frontal cortex, amygdala and hippocampus by microdialysis and HPLC. Levels of ACh in the hippocampus increased dose-dependently immediate...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Peptides
Volume:
25
Issue:
11
Pages:
1959-1969
Publication date:
2004-11-05
DOI:
EISSN:
1873-5169
ISSN:
0196-9781
URN:
uuid:2401e583-9b3e-44b3-b78a-3e91db734a01
Source identifiers:
241441
Local pid:
pubs:241441

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