- Abstract:
-
Substance P (SP) has memory-promoting, reinforcing and anxiolytic-like effects when applied systemically or centrally. Such effects may be mediated by the neurokinin-1 (NK-1) receptor, since SP preferentially binds to this receptor. We measured the effects of a selective non-peptide NK-1 receptor antagonist, SR140333 (1, 3 and 9 mg/kg i.p.) on ACh levels in frontal cortex, amygdala and hippocampus by microdialysis and HPLC. Levels of ACh in the hippocampus increased dose-dependently immediate...
Expand abstract - Publisher copy:
- 10.1016/j.peptides.2004.07.003
-
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- Journal:
- Peptides
- Volume:
- 25
- Issue:
- 11
- Pages:
- 1959-1969
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
-
1873-5169
- ISSN:
-
0196-9781
- URN:
-
uuid:2401e583-9b3e-44b3-b78a-3e91db734a01
- Source identifiers:
-
241441
- Local pid:
- pubs:241441
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects.
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