Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing.

Journal article

The establishment of an aerosol challenge model in nonhuman primates (NHPs) for the testing of vaccines against Mycobacterium tuberculosis would assist the global effort to optimize novel vaccination strategies. The endpoints used in preclinical challenge studies to identify measures of disease burden need to be accurate and sensitive enough to distinguish subtle differences and benefits afforded by different tuberculosis (TB) vaccine regimens when group sizes are inevitably small. This study...

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Authors: Sharpe, SA; Mcshane, H; Dennis, M; Basaraba, R; Gleeson, F

• Publication status: Published
• Journal: Clinical and vaccine immunology : CVI
• Volume: 17
• Issue: 8
• Pages: 1170-1182
• Publication date: 2010-08-01
• DOI: 10.1128/cvi.00079-10
• EISSN: 1556-679X
• ISSN: 1556-6811
• Language: English
• Keywords: Inhalation; Interferon-gamma; Biological Markers; Disease Models, Animal; Tuberculosis Vaccines; Magnetic Resonance Imaging; Humans; Mycobacterium tuberculosis; Survival Analysis; Macaca mulatta; Lung; Leukocytes, Mononuclear; Tuberculosis, Pulmonary; Primate Diseases; Endpoint Determination; Animals; Cell Proliferation; Aerosols; Radiography, Thoracic