Journal article icon

Journal article

Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing.

Abstract:

The establishment of an aerosol challenge model in nonhuman primates (NHPs) for the testing of vaccines against Mycobacterium tuberculosis would assist the global effort to optimize novel vaccination strategies. The endpoints used in preclinical challenge studies to identify measures of disease burden need to be accurate and sensitive enough to distinguish subtle differences and benefits afforded by different tuberculosis (TB) vaccine regimens when group sizes are inevitably small. This study...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/cvi.00079-10

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Clinical and vaccine immunology : CVI More from this journal
Volume:
17
Issue:
8
Pages:
1170-1182
Publication date:
2010-08-01
DOI:
EISSN:
1556-679X
ISSN:
1556-6811

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP