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Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis

Abstract:

Background: The question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence. We aimed to integrate the available evidence to create hierarchies of the comparative efficacy, risk of all-cause discontinuation, and major side-effects of antipsychotic drugs. Methods: We did a Bayesian-framework, multiple-treatments meta-analysis (which uses both dir...

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Journal:
The Lancet
Volume:
382
Issue:
9896
Pages:
951-962
Publication date:
2013-01-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:23ec0184-28a3-4582-b410-05375a7b7f57
Source identifiers:
430213
Local pid:
pubs:430213

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