Journal article
Synthesis and glycosidase inhibition of broussonetine M and its analogues
- Abstract:
-
Cross-metathesis (CM) and Keck asymmetric allylation, which allows access to defined stereochemistry of a remote side chain hydroxyl group, are the key steps in a versatile synthesis of broussonetine M (3) from the d-arabinose-derived cyclic nitrone 14. By a similar strategy, ent-broussonetine M (ent-3) and six other stereoisomers have been synthesized, respectively, starting from l-arabino-nitrone (ent-14), l-lyxo-nitrone (ent-3-epi-14), and l-xylo-nitrone (2-epi-14) in five steps, in 26%–31...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Molecules Journal website
- Volume:
- 24
- Issue:
- 20
- Article number:
- 3712
- Publication date:
- 2019-10-15
- Acceptance date:
- 2019-10-14
- DOI:
- EISSN:
-
1420-3049
- ISSN:
-
1420-3049
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1065729
- UUID:
-
uuid:23d9a2ca-d3bd-4e27-ad50-e958be7c5924
- Local pid:
- pubs:1065729
- Source identifiers:
-
1065729
- Deposit date:
- 2019-10-27
Terms of use
- Copyright holder:
- Wu et al
- Copyright date:
- 2019
- Notes:
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record