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Thesis

Characterization of pilE antisense RNA in Neisseria meningitidis

Abstract:

Expression of Type four pili is important for colonization and virulence in Neisseria meningitidis, which is a major causative agent of bacterial meningitis and septicaemia. Pili mediate adhesion, twitching motility, DNA uptake, and can be subject to phase and antigenic variation (Av). Pilin expression and Av may be modulated in response to environmental cues; however, the mechanisms of regulation are still unclear.

This work demonstrates the identification of a novel cis-...

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Department:
Pathology

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Department:
Pathology
Role:
Supervisor
Department:
Pathology
Role:
Supervisor
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Funding agency for:
Felicia Tan
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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