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Journal article

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumour effects in preclinical prostate cancer

Abstract:

Background: There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tumour vessels. There is interest in expanding the use of VTP to higher-risk disease. Tumour vasculature is characterised by vessel immaturity, increased permeability, aberrant branching and inefficient flow. FRT alters the tumou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-021-01450-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0001-5148-0161
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Name:
Cancer Research UK
Grant:
22748
Publisher:
Springer Nature
Journal:
British Journal of Cancer More from this journal
Volume:
125
Issue:
2021
Pages:
534–546
Publication date:
2021-06-21
Acceptance date:
2021-05-25
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
1178794
Local pid:
pubs:1178794
Deposit date:
2021-05-26

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