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CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.

Abstract:

Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames for known functional proteins as well as numerous alternative reading frames (ARFs). At least some ARFs have the potential to encode proteins of unknown function, and their antigenic properties can be considered as cryptic epitopes (CEs). To examine the extent of active immune...

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Publisher copy:
10.1084/jem.20092060

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Journal:
Journal of experimental medicine More from this journal
Volume:
207
Issue:
1
Pages:
51-59
Publication date:
2010-01-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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