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Human bone marrow osteoprogenitors express estrogen receptor-alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation.

Abstract:

Understanding the mechanisms that control the proliferation and commitment of human stem cells into cells of the osteogenic lineage for the preservation of skeletal structure is of basic importance in bone physiology. This study examines some aspects of the differentiation in vitro of human bone marrow fibroblastic cells cultured in the absence (basal media) or presence of 1nM dexamethasone and 50 micrograms/ml ascorbate for 6, 10, 14, and 21 days. Northern blot analysis and in situ hybridisa...

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Publication status:
Published

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Authors


Oreffo, RO More by this author
Romberg, S More by this author
Triffitt, JT More by this author
Journal:
Journal of cellular biochemistry
Volume:
75
Issue:
3
Pages:
382-392
Publication date:
1999-12-05
DOI:
EISSN:
1097-4644
ISSN:
0730-2312
URN:
uuid:23bb71ae-feb1-4cef-b449-0be5ce99ed4f
Source identifiers:
108761
Local pid:
pubs:108761

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