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Application of Human Stem Cell−derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG

Abstract:

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arrhythmic ability is lacking. Under standardized conditions, we have evaluated the sensitivity of hESC-CM to proarrhythmic provocations by blockade of hERG and other channels. Using voltage patch clamp, some ion current densities (pA/pF) in...

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Publisher copy:
10.1016/j.yjmcc.2012.02.002

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Journal:
Journal of Molecular and Cellular Cardiology
Volume:
52
Issue:
5
Pages:
998-1008
Publication date:
2012-01-01
DOI:
UUID:
uuid:23bb023a-5a20-4630-8602-35326824ecb7
Local pid:
cs:5834
Deposit date:
2015-03-31

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