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LENS - a clinical trial embedded in routine clinical practice to reduce the burden of diabetic eye disease

Abstract:
Embedding clinical trials in routine clinical care provides the opportunity to enhance efficiency and reduce costs. Diabetic retinopathy (DR) remains a common cause of blindness and impaired vision and treatment of advanced DR is costly. However, few trials have been designed to investigate treatments which may retard progression from observable DR to advanced DR because the condition usually progresses slowly, it is challenging to identify patients at risk of progression to clinically significant DR without retinal imaging and studies require medical professionals and specialist equipment to capture and grade retinal images. This highlights the need for streamlined trials which can identify large numbers of eligible patients and follow them cost-effectively for extended periods.
Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher copy:
10.1186/s13063-017-1902-y

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-3139-1836
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author


Publisher:
BioMed Central
Host title:
4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials
Journal:
4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials More from this journal
Publication date:
2017-05-01
Acceptance date:
2016-11-21
DOI:
ISSN:
1745-6215


Pubs id:
pubs:735132
UUID:
uuid:23b7c1fb-2cc1-4a82-b369-297a355fc57f
Local pid:
pubs:735132
Source identifiers:
735132
Deposit date:
2017-12-30

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