Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

Journal article

BACKGROUND AND PURPOSE: Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. The aim of this study was to evaluate the antitumor activity of a high CAIX-affinity indanesulfonamide (11c) combined with irradiation, compared with the general CA inhibitor acetazolamide (AZA). MATERIAL AND METHODS: HT-29 carcinoma cells with or without (genetic knockdown,...

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Authors: Dubois, L; Peeters, S; Lieuwes, N; Geusens, N; Thiry, A

• Publication status: Published
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• Volume: 99
• Issue: 3
• Pages: 424-431
• Publication date: 2011-06-01
• DOI: 10.1016/j.radonc.2011.05.045
• EISSN: 1879-0887
• ISSN: 0167-8140
• Language: English
• Keywords: Apoptosis; Flow Cytometry; Humans; Statistics, Nonparametric; Mice; Carbonic Anhydrase Inhibitors; Animals; Lactic Acid; HT29 Cells; Cell Proliferation; Cell Hypoxia; Real-Time Polymerase Chain Reaction; Mice, Nude; Acetazolamide; Immunoblotting