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Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

Abstract:

BACKGROUND AND PURPOSE: Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. The aim of this study was to evaluate the antitumor activity of a high CAIX-affinity indanesulfonamide (11c) combined with irradiation, compared with the general CA inhibitor acetazolamide (AZA). MATERIAL AND METHODS: HT-29 carcinoma cells with or without (genetic knockdown,...

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Publication status:
Published

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Journal:
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology More from this journal
Volume:
99
Issue:
3
Pages:
424-431
Publication date:
2011-06-01
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
Language:
English
Keywords:
Pubs id:
pubs:162252
UUID:
uuid:23b6086f-62a2-4001-9b12-35e5e8733afa
Local pid:
pubs:162252
Source identifiers:
162252
Deposit date:
2012-12-19

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