Journal article : Review
Ischemia and reperfusion injury in kidney transplantation: Relevant mechanisms in injury and repair
- Abstract:
- Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 3.5MB, Terms of use)
-
- Publisher copy:
- 10.3390/jcm9010253
Authors
- Publisher:
- MDPI
- Journal:
- Journal of Clinical Medicine More from this journal
- Volume:
- 9
- Issue:
- 1
- Article number:
- 253
- Publication date:
- 2020-01-17
- Acceptance date:
- 2020-01-13
- DOI:
- EISSN:
-
2077-0383
- Pmid:
-
31963521
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1083873
- Local pid:
-
pubs:1083873
- Deposit date:
-
2020-10-05
- ARK identifier:
Terms of use
- Copyright holder:
- GJ Nieuwenhuijs-Moeke et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record