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Journal article

Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.

Abstract:

The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For antigenic variation to work, not only must the vast VSG repertoire be kept silent in a genome that is mainly constitutively transcribed, but the frequency of VSG switching must be ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1003010

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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
8
Issue:
11
Pages:
e1003010
Publication date:
2012-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
358079
Language:
English
Keywords:
UUID:
uuid:239eebab-c548-48a4-b6da-c1fed636e170
Local pid:
pubs:358079
Deposit date:
2013-11-16

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