Journal article
Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.
- Abstract:
-
The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For antigenic variation to work, not only must the vast VSG repertoire be kept silent in a genome that is mainly constitutively transcribed, but the frequency of VSG switching must be ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Wellcome Trust
More from this funder
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 8
- Issue:
- 11
- Pages:
- e1003010
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7366
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:239eebab-c548-48a4-b6da-c1fed636e170
- Local pid:
- pubs:358079
- Source identifiers:
-
358079
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Povelones et al
- Copyright date:
- 2012
- Notes:
- © 2012 Povelones et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record