Journal article
ASYMMETRIC-SYNTHESIS OF SYN-ALPHA-ALKYL-BETA-AMINO ACIDS
- Abstract:
-
An investigation into the reactivity of the highly stereoselective conjugate nucleophile lithium N-benzyl-N-α-methylbenzylamide 1 with α-alkyl-α,β-unsaturated esters has led to the development of a versatile asymmetric synthesis of syn-α-alkyl-β-amino acids. By performing the conjugate additions in toluene and diluting the reaction mixtures with THF prior to quenching of the reactions with the hindered acid. 2,6-di-tert-butylphenol 13, the product syn-α-alkyl-β-amino esters may be generated i...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
- Volume:
- 9
- Issue:
- 9
- Pages:
- 1141-1147
- Publication date:
- 1994-05-07
- DOI:
- EISSN:
-
1364-5463
- ISSN:
-
0300-922X
Item Description
- Pubs id:
-
pubs:168605
- UUID:
-
uuid:2396e4f2-242b-4d8c-bd0b-0252c356f6ac
- Local pid:
- pubs:168605
- Source identifiers:
-
168605
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1994
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