Immunogenicity and efficacy of conjugated and unconjugated Vi-polysaccharide vaccines in the prevention of typhoid fever

Thesis

Each year, 12.1 to 20.6 million typhoid fever infections occur globally, of which 1% result in death. Children are particularly susceptible to infection. As the causative bacterium Salmonella Typhi is transmitted via contaminated food or unsafe drinking water, typhoid fever has often been regarded as a disease of poverty or an infection of the returning traveller. However, increasing antimicrobial resistance and reduced treatment options have made typhoid fever a global threat. Interventio...

Expand abstract

Authors: Jin, C

• Alternative title: Vaccines against Salmonella Typhi
• DOI: 10.5287/ora-ve6wyzogy
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford