- Abstract:
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Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcome...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 395.7KB)
-
- Publisher copy:
- 10.1186/s12884-017-1594-z
-
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- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Pregnancy and Childbirth Journal website
- Volume:
- 17
- Issue:
- 1
- Pages:
- Article: 440
- Publication date:
- 2017-12-28
- Acceptance date:
- 2017-11-23
- DOI:
- ISSN:
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1471-2393
- Pubs id:
-
pubs:817186
- URN:
-
uri:236b7a59-ce89-4fcc-bb5f-ad875cd8fc4d
- UUID:
-
uuid:236b7a59-ce89-4fcc-bb5f-ad875cd8fc4d
- Local pid:
- pubs:817186
- Paper number:
- 1
- Language:
- English
- Keywords:
- Copyright holder:
- Pels et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Journal article
STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials
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Canadian Institutes of Health Research
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