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STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials

Abstract:

Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcome...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12884-017-1594-z

Authors


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Role:
Author
ORCID:
0000-0003-4136-3070
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Grant:
Grant (Neonatal Sub-study
Canadian Institutes of Health Research More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Pregnancy and Childbirth Journal website
Volume:
17
Issue:
1
Article number:
440
Publication date:
2017-12-28
Acceptance date:
2017-11-23
DOI:
ISSN:
1471-2393
Pmid:
29282009
Source identifiers:
817186
Language:
English
Keywords:
Pubs id:
pubs:817186
UUID:
uuid:236b7a59-ce89-4fcc-bb5f-ad875cd8fc4d
Local pid:
pubs:817186
Deposit date:
2018-02-25

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