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STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials

Abstract:

Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcome...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12884-017-1594-z

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Role:
Author
ORCID:
0000-0003-4136-3070
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Grant:
Grant (Neonatal Sub-study)
Canadian Institutes of Health Research More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Pregnancy and Childbirth Journal website
Volume:
17
Issue:
1
Pages:
Article: 440
Publication date:
2017-12-28
Acceptance date:
2017-11-23
DOI:
ISSN:
1471-2393
Pubs id:
pubs:817186
URN:
uri:236b7a59-ce89-4fcc-bb5f-ad875cd8fc4d
UUID:
uuid:236b7a59-ce89-4fcc-bb5f-ad875cd8fc4d
Local pid:
pubs:817186
Paper number:
1

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