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The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α

Abstract:

Farnesylated prelamin A accumulates when the final endoproteolytic maturation of the protein fails to occur and causes a dysmorphic nuclear phenotype; however, the morphology and mechanisms of biogenesis of these changes remain unclear. We show here that acute prelamin A accumulation after reduction in the activity of the ZMPSTE24 endoprotease by short interfering RNA knockdown, results in the generation of a complex nucleoplasmic reticulum that depends for its formation on the enzyme CTP:pho...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/jcs.091009

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Vaux
Oxford college:
Trinity College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Vaux
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Vaux
Oxford college:
Lincoln College
Role:
Principal Investigator (PI), Author
More from this funder
Funding agency for:
Goulbourne, C
Grant:
G0801917
More from this funder
Funding agency for:
Vaux, D
Grant:
G0801917
Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
124
Issue:
24
Pages:
4253-4266
Publication date:
2011-12-01
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Language:
English
Keywords:
UUID:
uuid:2363ea2e-8141-40e3-ab49-b1920ccb2e2c
Local pid:
ora:6145
Deposit date:
2012-03-26

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