- Abstract:
-
The common and persistent failures to translate promising preclinical drug candidates into clinical success highlight the limited effectiveness of disease models currently used in drug discovery. An apparent reluctance to explore and adopt alternative cell- and tissue-based model systems, coupled with a detachment from clinical practice during assay validation, contributes to ineffective translational research. To help address these issues and stimulate debate, here we propose a set of princi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
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(jpeg, 886.5KB)
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(pdf, 424.5KB)
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- Publisher copy:
- 10.1038/nrd.2016.175
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Reviews Drug Discovery Journal website
- Volume:
- 15
- Issue:
- 11
- Pages:
- 751–769
- Publication date:
- 2016-09-12
- Acceptance date:
- 2016-01-01
- DOI:
- EISSN:
-
1474-1784
- ISSN:
-
1474-1776
- Pubs id:
-
pubs:642715
- URN:
-
uri:235b737c-1b92-4b81-9819-ab300ce36eb9
- UUID:
-
uuid:235b737c-1b92-4b81-9819-ab300ce36eb9
- Local pid:
- pubs:642715
- Paper number:
- 11
- Language:
- English
- Keywords:
- Copyright holder:
- Horvath et al.
- Copyright date:
- 2016
- Notes:
-
© the Author(s), published by Nature Publishing Group. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Groupat: https://doi.org/10.1038/nrd.2016.175
Journal article
Screening out irrelevant cell-based models of disease
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