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Screening out irrelevant cell-based models of disease

Abstract:

The common and persistent failures to translate promising preclinical drug candidates into clinical success highlight the limited effectiveness of disease models currently used in drug discovery. An apparent reluctance to explore and adopt alternative cell- and tissue-based model systems, coupled with a detachment from clinical practice during assay validation, contributes to ineffective translational research. To help address these issues and stimulate debate, here we propose a set of princi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nrd.2016.175

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Funding agency for:
Ebner, D
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Drug Discovery Journal website
Volume:
15
Issue:
11
Pages:
751–769
Publication date:
2016-09-12
Acceptance date:
2016-01-01
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
Pmid:
27616293
Source identifiers:
642715
Language:
English
Keywords:
Pubs id:
pubs:642715
UUID:
uuid:235b737c-1b92-4b81-9819-ab300ce36eb9
Local pid:
pubs:642715
Deposit date:
2016-09-27

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