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Interactome rewiring following pharmacological targeting of BET bromodomains

Abstract:

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canoni...

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Publication status:
Published
Peer review status:
Peer reviewed

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More from this funder
Name:
Ludwig Institute
Funding agency for:
Filippakopoulos, P
Grant:
095751/Z/11/Z
More from this funder
Name:
Wellcome Trust
Funding agency for:
Filippakopoulos, P
Grant:
095751/Z/11/Z
Publisher:
Elsevier
Journal:
Molecular Cell More from this journal
Volume:
73
Issue:
3
Pages:
621-638.e17
Publication date:
2018-12-13
Acceptance date:
2018-11-02
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:941091
UUID:
uuid:235a4867-6778-4fdb-a4e1-a1a69c218d62
Local pid:
pubs:941091
Deposit date:
2018-11-12

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