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Sequence balance minimisation: minimising with unequal treatment allocations

Abstract:

Background
Minimisation ensures excellent balance between groups for several prognostic factors, even in small samples. However, its use with unequal allocation ratios has been problematic. This paper describes a new minimisation scheme named sequence balance minimisation for unequal treatment allocations.

Methods
Treatment- and factor-balancing properties were assessed in simulation studies for two- and three-arm trials with 1:2 and 1:2:3 allocation ratios. Sample sizes were...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
Publisher:
BioMed Central
Journal:
Trials More from this journal
Volume:
18
Issue:
1
Article number:
207
Publication date:
2017-05-03
Acceptance date:
2017-04-11
DOI:
EISSN:
1745-6215
Pmid:
28468678
Language:
English
Keywords:
Pubs id:
1104796
Local pid:
pubs:1104796
Deposit date:
2020-09-02

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