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Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

Abstract:

Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride channels in various tissues. One technical hurdle in studying these channels is the well-known channel rundown that frequently impairs the precision of electrophysiological measurements for the channels. Using experimental protocols that employ fast-solution...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0086734

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author

Contributors

Role:
Editor
Publisher:
PLOS
Journal:
PLoS ONE More from this journal
Volume:
9
Issue:
1
Article number:
e86734
Publication date:
2014-01-29
DOI:
EISSN:
1932-6203
Pubs id:
pubs:579184
UUID:
uuid:234d69e6-189d-4f89-85e0-b53b85b069b0
Local pid:
pubs:579184
Source identifiers:
579184
Deposit date:
2015-12-09

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