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Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

Abstract:

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentrations can help to assess their causal role in disease. However, a more complex relationship between the genetic variants and an exposure can make findings from MR more difficult to interpret. In this R...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nrcardio.2017.78

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Cardiology Journal website
Volume:
14
Issue:
10
Pages:
577-590
Publication date:
2017-06-01
Acceptance date:
2017-01-01
DOI:
EISSN:
1759-5010
ISSN:
1759-5002
Pubs id:
pubs:700649
URN:
uri:23486dfb-a679-4b9a-8fcd-3971339c58f1
UUID:
uuid:23486dfb-a679-4b9a-8fcd-3971339c58f1
Local pid:
pubs:700649
Paper number:
10

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