Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion.

Journal article

Symptomatic severe malarial anaemia (SMA) has a high fatality rate of 30-40%; most deaths occur in children awaiting blood transfusion. Blood transfusion services in most of Africa are not capable of delivering adequate supplies of safe blood in a timely manner to critically ill children with SMA. Contrary to widely held belief, hypovolaemia, rather than heart failure, has emerged as a common complication in such children. We examined the safety of pre-transfusion management (PTM) by volume e...

Expand abstract

Authors: Maitland, K; Pamba, A; English, M; Peshu, N; Levin, M

• Publication status: Published
• Journal: British journal of haematology
• Volume: 128
• Issue: 3
• Pages: 393-400
• Publication date: 2005-02-01
• DOI: 10.1111/j.1365-2141.2004.05312.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Fluid Therapy; Treatment Outcome; Plasma Substitutes; Kenya; Malaria, Falciparum; Child, Preschool; Hypovolemia; Blood Transfusion; Developing Countries; Infant; Anemia; Humans; Survival Analysis