Journal article

Oxygen sensing by HIF hydroxylases.

Abstract:: The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.

Publication status:: Published

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APA Style

Schofield, C., & Ratcliffe, P. (2004). Oxygen sensing by HIF hydroxylases. Nature Reviews. Molecular Cell Biology, 5(5), 343–354.

MLA Style

Schofield, C, and P Ratcliffe. “Oxygen Sensing by HIF Hydroxylases.” Nature Reviews. Molecular Cell Biology, vol. 5, no. 5, 2004, pp. 343–54.

Chicago Style

Schofield, C, and P Ratcliffe. 2004. “Oxygen Sensing by HIF Hydroxylases.” Nature Reviews. Molecular Cell Biology 5 (5): 343–54.
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Publisher copy:: 10.1038/nrm1366

Authors

+ Schofield, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Ratcliffe, P More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: CCMP
Role:: Author

Journal:: Nature reviews. Molecular cell biology More from this journal
Volume:: 5
Issue:: 5
Pages:: 343-354
Publication date:: 2004-05-01
DOI:: 10.1038/nrm1366
EISSN:: 1471-0080
ISSN:: 1471-0072

Language:: English
Keywords:: Hydroxylation

Cell Hypoxia

Animals

Oxygen

Gene Expression Regulation

Oxygenases

Humans

Hypoxia-Inducible Factor 1, alpha Subunit

Ketoglutaric Acids

Transcription Factors
Pubs id:: pubs:27809
UUID:: uuid:23401cd4-3015-43b8-966c-fe734ec82644
Local pid:: pubs:27809
Source identifiers:: 27809
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_23401cd4301543b8966cfe734ec82644

Terms of use

Copyright date:: 2004

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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