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Journal article

5-HT2C receptor activation decreases appetite and body weight in obese subjects.

Abstract:

We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial, mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger. Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C...

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Publication status:
Published

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Publisher copy:
10.1007/s002130050407

Authors


Sargent, PA More by this author
Sharpley, AL More by this author
Williams, C More by this author
Goodall, EM More by this author
Journal:
Psychopharmacology
Volume:
133
Issue:
3
Pages:
309-312
Publication date:
1997-10-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:23375576-6a59-44f4-bce5-0e853c5a79ce
Source identifiers:
186049
Local pid:
pubs:186049

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