We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial, mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger. Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
5-HT2C receptor activation decreases appetite and body weight in obese subjects.
If you are the owner of this record, you can report an update to it here: Report update to this record