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Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity.

Abstract:

In exploratory animal models of anxiety, such as the elevated plus maze, the anxiogenic- and anxiolytic-like effects of drugs may be confounded by changes in locomotor activity. In the present experiments, the sensitivity of several measures of anxiety and locomotor activity in the elevated plus maze were assessed. Both chlordiazepoxide hydrochloride (CDP, 7.5 mg/kg) and d-amphetamine sulphate (AMP, 0.75, 1.5 mg/kg) increased the percent time on the open arms and doses of 7.5 mg/kg and 1.5 mg...

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Publication status:
Published

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Publisher copy:
10.1007/bf02245961

Authors


Dawson, GR More by this author
Crawford, SP More by this author
Collinson, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Tricklebank, MD More by this author
Journal:
Psychopharmacology
Volume:
118
Issue:
3
Pages:
316-323
Publication date:
1995-04-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:231deefc-4125-47a7-b7f7-23ec28a89adf
Source identifiers:
22316
Local pid:
pubs:22316

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