- Abstract:
-
In exploratory animal models of anxiety, such as the elevated plus maze, the anxiogenic- and anxiolytic-like effects of drugs may be confounded by changes in locomotor activity. In the present experiments, the sensitivity of several measures of anxiety and locomotor activity in the elevated plus maze were assessed. Both chlordiazepoxide hydrochloride (CDP, 7.5 mg/kg) and d-amphetamine sulphate (AMP, 0.75, 1.5 mg/kg) increased the percent time on the open arms and doses of 7.5 mg/kg and 1.5 mg...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf02245961
-
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- Journal:
- Psychopharmacology
- Volume:
- 118
- Issue:
- 3
- Pages:
- 316-323
- Publication date:
- 1995-04-05
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:231deefc-4125-47a7-b7f7-23ec28a89adf
- Source identifiers:
-
22316
- Local pid:
- pubs:22316
- Language:
- English
- Keywords:
- Copyright date:
- 1995
Journal article
Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity.
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