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Different pathways of colorectal carcinogenesis and their clinical pictures.

Abstract:
An entertaining debate in cancer genetics concerns the relative importance of selection for a growth advantage and genomic instability in tumorigenesis. Below, I present evidence that shows that selection is more important, particularly in the early stages of tumorigenesis, but that genomic instability is also an indisputable feature of many cancers. One attractive possibility is that some mutations may have pleiotropic effects both on cell replication or apoptosis and on genomic instability.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Annals of the New York Academy of Sciences
Volume:
910
Pages:
10-18
Publication date:
2000-06-05
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:22fd775b-b2a5-4a1c-a9c5-5a21f4ac90e4
Source identifiers:
72016
Local pid:
pubs:72016

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