Journal article

Chemistry-to-gene screens in Caenorhabditis elegans.

Abstract:: The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.

Publication status:: Published

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APA Style

Jones, A., Buckingham, S., & Sattelle, D. (2005). Chemistry-to-gene screens in Caenorhabditis elegans. Nature Reviews. Drug Discovery, 4(4), 321–330.

MLA Style

Jones, A, et al. “Chemistry-to-Gene Screens in Caenorhabditis Elegans.” Nature Reviews. Drug Discovery, vol. 4, no. 4, 2005, pp. 321–30.

Chicago Style

Jones, A, S Buckingham, and D Sattelle. 2005. “Chemistry-to-Gene Screens in Caenorhabditis Elegans.” Nature Reviews. Drug Discovery 4 (4): 321–30.
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Publisher copy:: 10.1038/nrd1692

Authors

+ Jones, A More by this author

Role:: Author

+ Buckingham, S More by this author

Role:: Author

+ Sattelle, D More by this author

Role:: Author

Journal:: Nature reviews. Drug discovery More from this journal
Volume:: 4
Issue:: 4
Pages:: 321-330
Publication date:: 2005-04-01
DOI:: 10.1038/nrd1692
EISSN:: 1474-1784
ISSN:: 1474-1776

Language:: English
Keywords:: Animals

Antinematodal Agents

Genes, Helminth

Drug Design

Drug Resistance

Caenorhabditis elegans

Models, Animal
Pubs id:: pubs:244242
UUID:: uuid:22fc9f9f-81da-472a-93c3-f6b0b51a2f82
Local pid:: pubs:244242
Source identifiers:: 244242
Deposit date:: 2013-11-16
ARK identifier:: ark:/29072/ora_22fc9f9f81da472a93c3f6b0b51a2f82

Terms of use

Copyright date:: 2005

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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