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Journal article

Chemistry-to-gene screens in Caenorhabditis elegans.

Abstract:
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
Publication status:
Published

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Publisher copy:
10.1038/nrd1692
Journal:
Nature reviews. Drug discovery More from this journal
Volume:
4
Issue:
4
Pages:
321-330
Publication date:
2005-04-01
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
Language:
English
Keywords:
Pubs id:
pubs:244242
UUID:
uuid:22fc9f9f-81da-472a-93c3-f6b0b51a2f82
Local pid:
pubs:244242
Source identifiers:
244242
Deposit date:
2013-11-16

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