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Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation

Abstract:

Because of β-lactamase–mediated resistance, β-lactam antibiotics were long considered ineffective drugs for tuberculosis (TB) treatment. However, some β-lactams, including meropenem and faropenem, are being re-evaluated in patients infected with TB. Penicillin-binding protein (PBP) 3, or ftsI, is an essential transpeptidase in Mycobacterium tuberculosis (Mtb) required for cell division, and thus it is an important drug target. Structures of apo MtbPBP3 and of complexes with five β-lactams, in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1124/mol.119.118042

Authors


Publisher:
American Society for Pharmacology and Experimental Therapeutics
Journal:
Molecular Pharmacology More from this journal
Volume:
97
Issue:
4
Pages:
287-294
Publication date:
2020-02-28
Acceptance date:
2020-01-14
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
Pmid:
32086254
Language:
English
Keywords:
Pubs id:
1089150
Local pid:
pubs:1089150
Deposit date:
2020-03-31

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