Thesis
Fabrication of perfusion microbioreactor for culturing engineered heart tissue with electrical stimulation
- Abstract:
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This thesis focuses on fabricating a perfused microbioreactor platform to generate functional human engineered heart tissue to be used for drug testing. To evaluate the feasibility of this system and make the conditions optimized for culturing cardiomyocytes in 3D constructs, rats’ heart tissue models were firstly set up to test the efficacy for long-term culture. Myocytes from embryonic rats were cultured in 200mg/ml fibrinogen gel with 5 million/ml cell densities. The tissues were formed...
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- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- UUID:
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uuid:22d1e316-f0aa-40ed-a1f7-84c4788e2b97
- Deposit date:
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2020-03-06
Terms of use
- Copyright holder:
- Liu, X
- Copyright date:
- 2019
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