Journal article : Review
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
- Abstract:
- With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children < 2 years and elderly ⩾ 65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, 167.4KB, Terms of use)
-
- Publisher copy:
- 10.1007/s11684-019-0733-5
Authors
- Publisher:
- Springer Verlag
- Journal:
- Frontiers of medicine More from this journal
- Volume:
- 14
- Issue:
- 1
- Pages:
- 1-7
- Publication date:
- 2019-12-10
- Acceptance date:
- 2019-10-31
- DOI:
- EISSN:
-
2095-0225
- ISSN:
-
2095-0217
- Pmid:
-
31823287
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1077744
- Local pid:
-
pubs:1077744
- Deposit date:
-
2020-03-09
Terms of use
- Copyright holder:
- Zhou et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. This article is published with open access at link.springer.com and journal.hep.com.cn. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record