Journal article icon

Journal article

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Abstract:

Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration.To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes.Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes. Evid...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1136/annrheumdis-2012-203146

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Expand authors...
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the rheumatic diseases Journal website
Volume:
73
Issue:
7
Pages:
1405-1413
Publication date:
2014-01-01
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:22a35877-66c3-4807-9a3d-a653e5e8696b
Source identifiers:
401925
Local pid:
pubs:401925

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP