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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Abstract:

Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration.To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes.Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes. Evid...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/annrheumdis-2012-203146

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the rheumatic diseases Journal website
Volume:
73
Issue:
7
Pages:
1405-1413
Publication date:
2014-01-01
Acceptance date:
2013-05-07
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Source identifiers:
401925

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