- Abstract:
-
Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration.To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes.Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes. Evid...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.2MB)
-
- Publisher copy:
- 10.1136/annrheumdis-2012-203146
-
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- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Annals of the rheumatic diseases Journal website
- Volume:
- 73
- Issue:
- 7
- Pages:
- 1405-1413
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1468-2060
- ISSN:
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0003-4967
- URN:
-
uuid:22a35877-66c3-4807-9a3d-a653e5e8696b
- Source identifiers:
-
401925
- Local pid:
- pubs:401925
- Language:
- English
- Keywords:
- Copyright holder:
- Poulsen et al.
- Copyright date:
- 2014
- Notes:
- This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
Journal article
Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
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