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Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro

Abstract:

Osteoarthritis (OA) is a common cause of pain and disability and is often associated with the degeneration of articular cartilage. Lesions to the articular surface, which are thought to progress to OA, have the potential to be repaired using tissue engineering strategies; however, it remains challenging to instruct cell differentiation within a scaffold to produce tissue with appropriate structural, chemical and mechanical properties. We aimed to address this by driving progenitor cells to ad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep43519

Authors


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Name:
Leverhulme Trust
Funding agency for:
Gentleman, E
Grant:
Philip Leverhulme Prize
More from this funder
Name:
Wellcome Trust
Funding agency for:
Gentleman, E
Grant:
Philip Leverhulme Prize
More from this funder
Name:
US Department of Veterans Affairs
Funding agency for:
Brand, D
More from this funder
Name:
National Institute of Health Research - Biomedical Research Centre
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
43519
Pages:
1-10
Publication date:
2017-03-03
Acceptance date:
2017-01-25
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:685342
UUID:
uuid:22961cf1-2128-442f-abc1-90616427475b
Local pid:
pubs:685342
Source identifiers:
685342
Deposit date:
2017-04-28

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