Journal article icon

Journal article

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

Abstract:

A kinetic analysis was performed for the novel 1-(8-phosphonooctyl)-6-amino-5-bromouracil and 1-(8-phosphonooctyl)-7-deazaxanthine inhibitors of Escherichia coli thymidine (dThd) phosphorylase (TPase). The structure of the compounds was rationally designed based on the available crystal structure coordinates of bacterial TPase. These inhibitors reversibly inhibited TPase. Kinetic analysis revealed that the compounds inhibited TPase in a purely competitive or mixed fashion not only when dThd, ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Journal:
FEBS letters More from this journal
Volume:
483
Issue:
2-3
Pages:
181-185
Publication date:
2000-10-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:20834
UUID:
uuid:226d07bd-367c-414f-bc90-1ffd1e5f54bf
Local pid:
pubs:20834
Source identifiers:
20834
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP