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Journal article

Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics.

Abstract:

Ligand-dependent signalling pathways have been characterised as having morphogen properties where there is a quantitative relationship between receptor activation and response, or threshold characteristics in which there is a binary switch in response at a fixed level of receptor activation. Here we report the use of a bacterial artificial chromosome (BAC)-based transgenic system in which a hypermorphic mutation has been introduced into the murine Fgfr1 gene. These mice exhibit cranial suture...

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Publication status:
Published

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Publisher copy:
10.1242/dev.00940

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Journal:
Development (Cambridge, England)
Volume:
131
Issue:
2
Pages:
325-335
Publication date:
2004-01-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:225134cc-b2fc-446a-86f5-199adecb1e16
Source identifiers:
119899
Local pid:
pubs:119899

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