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Olanzapine versus divalproex versus placebo in the treatment of mild to moderate mania: a randomized, 12-week, double-blind study.

Abstract:

OBJECTIVE: To evaluate the efficacy and safety of olanzapine, divalproex, and placebo in a randomized, double-blind trial in mild to moderate mania (DSM-IV-TR criteria). METHOD: The study was conducted from October 2004 to December 2006. A total of 521 patients from private practices, hospitals, and university clinics were randomly assigned to olanzapine (5-20 mg/day), divalproex (500-2500 mg/day), or placebo for 3 weeks; those completing continued with a 9-week double-blind extension. Effic...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
The Journal of clinical psychiatry
Volume:
69
Issue:
11
Pages:
1776-1789
Publication date:
2008-11-05
EISSN:
1555-2101
ISSN:
0160-6689
URN:
uuid:224a2068-fec8-41f0-a953-0767ba8ae439
Source identifiers:
97929
Local pid:
pubs:97929

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